Immunohistochemical expression of p57 (Kip2) in first trimester abortion specimens of molar and non-Molar pregnancies

Outcome of Subsequent Pregnancies in Familial Molar Pregnancy

The demographics of molar pregnancies in BPKIHS.

This is an analysis of the incidence of molar pregnancies and those of complete and partial molar pregnancies across the reproductive age range for BP Koirala Institute of Health Sciences (BPKIHS) in the period 2010-2011. Patients with molar pregnancies registered with BPKIHS from January 2008 to January 2010 were identified. The overall number of molar pregnancies registered was compared to th...

Clinical implications of p57 KIP2 expression in breast cancer.

OBJECTIVE To study the relationship between expression of p57KIP2 and prognosis and other clinicopathological parameters in invasive breast cancers. METHODS We assessed the expression of p57KIP2 in 89 cases of invasive breast cancer and 20 cases of normal breast tissue by immunohistochemical methods and analyzed the results with SPSS software (ver. 16.0). RESULT The positive expression rate...

Molecular distinction of consecutive molar pregnancies.

BACKGROUND It may be difficult to differentiate the consecutive occurrence of two independent molar pregnancies from gestational trophoblastic neoplasia after the initial molar pregnancy, especially when the interval between them is short. CASE A 25-year-woman who had had a complete hydatidiform mole 6 months earlier presented with a 6-week history of secondary amenorrhea. Serum human chorion...

Significance of p57(Kip2) down-regulation in oncogenesis of bladder carcinoma: an immunohistochemical study.

AIMS AND BACKGROUND Cyclin-dependent kinase inhibitors have important roles in the oncogenesis of various tumors including urothelial cancer. The aim of this study was to establish the importance of p57(Kip2), a unique cyclin-dependent kinase inhibitor, in the oncogenesis of bladder carcinoma. This article also focused on another cyclin-dependent kinase inhibitor, p27(Kip1), and telomerase enzy...